What is a potential physical manifestation of Cushing syndrome related to fluid retention?

Cushing syndrome is characterized by excessive levels of cortisol in the body, which often leads to fluid retention. This condition results in a particular physical manifestation known as a "moon facies," where the face appears rounded and puffy due to the accumulation of fluid and fat deposits. This symptom is a direct result of changes in metabolism and enhanced sodium retention linked to elevated cortisol levels.

In contrast, the other options do not align with the manifestations of Cushing syndrome. Rapid weight loss would not occur; instead, individuals typically experience weight gain due to fluid retention and fat distribution changes. Increased muscle mass is also not a feature of Cushing syndrome; rather, muscle wasting can occur due to the catabolic effects of excess cortisol. Lastly, individuals with Cushing syndrome often feel fatigued and may have reduced energy levels due to hormonal imbalances and the stress their bodies endure, rather than increased energy.