Which endocrine disorder is characterized by a deficiency of both cortisol and aldosterone?

Addison's disease is characterized by a deficiency of both cortisol and aldosterone due to the dysfunction of the adrenal glands. In this condition, the adrenal glands do not produce enough hormones, particularly glucocorticoids like cortisol and mineralocorticoids like aldosterone. The lack of cortisol can lead to symptoms such as fatigue, weight loss, low blood pressure, and hypoglycemia. Meanwhile, a deficiency of aldosterone affects the body's ability to regulate sodium and potassium levels, which can result in electrolyte imbalances and dehydration.

Understanding this condition helps clarify its management, which often includes hormone replacement therapies to restore adequate levels of these critical hormones. The other disorders listed involve different mechanisms or hormonal imbalances that do not include the simultaneous deficiencies of cortisol and aldosterone, which is why they are not associated with Addison's disease.