Which of the following conditions is characterized by fatigue and weight gain?

The correct choice reflects a condition where fatigue and weight gain are significant symptoms. In hypothyroidism, the thyroid gland does not produce enough thyroid hormones, which are crucial for regulating metabolism. As a result, individuals with hypothyroidism often experience fatigue due to a slowed metabolism, leading to decreased energy levels.

Weight gain occurs as metabolic processes slow down, causing the body to convert calories into energy less efficiently. This weight gain can be accompanied by other symptoms, such as sensitivity to cold, dry skin, hair loss, and constipation, all stemming from the hormonal imbalance caused by insufficient thyroid hormone levels.

In contrast, the other conditions listed often present with symptoms opposite to those of hypothyroidism. For example, hyperthyroidism leads to increased metabolism, which results in weight loss and increased energy levels, while Cushing’s syndrome is characterized by fat redistribution and can lead to weight gain due to elevated cortisol levels, though fatigue is not always a primary symptom. Thyroid storm is an acute and severe manifestation of hyperthyroidism, presenting with extreme symptoms such as agitation and heat intolerance rather than fatigue and weight gain.